The fight-or-flight response (also called the fight, flight, freeze, or fawn response [in PTSD ], hyperarousal , or the acute stress response ) is a physiological reaction that occurs in response to a perceived harmful event , attack , or threat to survival. It was first described by Walter Bradford Cannon . His theory states that animals react to threats with a general discharge of the sympathetic nervous system , priming the animal for fighting or fleeing. More specifically, the adrenal medulla produces a hormonal cascade that results in the secretion of catecholamines , especially norepinephrine and epinephrine . The hormones estrogen , testosterone and cortisol , and the neurotransmitters dopamine and serotonin , also affect how organisms react to stress.